The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high resolution transcriptional atlas of rhesus monkey brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical parcellation of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons, and cortical layers and areas acquire adult-like molecular profiles surprisingly late postnatally. Disparate cell populations exhibit distinct developmental timing but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. The primate brain develops through a series of stereotyped processes that are conserved across mammals 1 , including the specification, migration and maturation of diverse cell types and the formation and refinement of functional neuronal circuits.
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As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. We confirm established associations between AD pathology and dementia, albeit with increased, presumably aging-related variability, and identify sets of co-expressed genes correlated with pathological tau and inflammation markers. Finally, we demonstrate a relationship between dementia and RNA quality, and find common gene signatures, highlighting the importance of properly controlling for RNA quality when studying dementia. The population of the United States is aging, with the fastest growth in the very oldest part of the population where the number of nonagenarians and centenarians are expected to increase from 2 million to 10 million by Corrada et al.
As a year-old parenting editor, I get the enormous pleasure of seeing every cute kids' movie a little bit early. I do my best to watch movies while keeping both parents and children in mind. Is there anything inappropriate or scary? Will little ones be able to sit through the entire thing?